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KMID : 0438219750120030625
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Korea University Medical Journal
1975 Volume.12 No. 3 p.625 ~ p.638
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Studies on the Correlation of Immunoglobulins with Liver Function Tests in the Cases of Hepatitis
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Abstract
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The immunoglobulins (IgG, IgA and IgM) have been estimated in 26 cases of acute viral hepatitis and 22 cases of chronic hepatitis who had been admitted to this clinic by means of agar immunodiffusion method and the correlation with liver function test was observed which had been performed at the same time. All of the cases were confirmed by liver biopsy and other clinical patterns. The correlation was determined by probability acquired with Fisher´s table after the correlation coefficient had been calculated statistically.
The following results were obtained in this report.
1. In acute viral hepatitis the slope is negative between the value of IgG and serum albumin to a certain degree and remarkably positive among total globulin, gamma globulin, S. G. 0. T. and T. T. T. In chronic hepatitis the slope is positive only among the value of IgG, serum albumin and T. T. T. and remarkably negative between the value of IgG and S. G. P. T.
2. The value of IgA shows the remarkable positive slope with gamma globulin, total bilirubin, alkaline phosphatase, S. G. O. T. and T.T.T. However, all of the cases of chronic hepatitis have no correlation.
3. In acute viral hepatitis the positive slope is observed among the value of IgM and total globulin, gamma globulin and T.T.T. In chronic hepatitis albumin, total globulin and gamma globulin shows positive slope but negative with total bilirubin, S. G. 0. T. and S. G. P. T.
4. No significant correlation coefficient is noted between the value of immunoglobulins (IgG, IgA, and IgM)´ and absolute lymphocyte count in acute viral hepatitis and chronic hepatitis.
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